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Is regional policy necessary? If so, under what circumstances? The first part of the chapter discusses the rationale behind the existence of (or the need for) regional policies in general. Cases in which excessive concentration or inequality hinders national economic growth are natural candidates for regional policies. If concentration and inequality favor national growth and competitiveness, regional interventions call for a different sort of argument, such as national unity or cohesion. Any regional policy has sectoral and national consequences, as well as any sectoral or national policy has regional consequences. Should public authorities engage in explicit regional policies (place-based) or in sectoral or social policies (people-based) with desirable regional implications? Finally, if regional policies are implemented, how to evaluate them? The chapter discusses these topics.